That's a very broad amount of genre ground to cover, but the overall premise of the setting allows for a campaign that can tackle
- straightforward "monster showdowns" ala From Dusk Till Dawn and Tales from the Crypt: Demon Knight;
- spooky atmospheric hauntings ala The Eye, The Grudge and The Ring;
- professionals taking on the weird ala X-Files, Supernatural, Dog Soldiers, and the little known film Double Vision (starring Tony Leung and David Morse);
- reality-bending, "the world you know is wrong" extravaganzas like Hellraiser and Silent Hill;
- science-gone-wrong outbreaks like Resident Evil and almost any zombie apocalypse movie;
- humans tampering with the natural order of things as in the cult film Cube and the riffs on The Island of Dr. Moreau;
- old standbys like cthulhoid elder gods, demons and devils, and trapped ancient evils.
System isn't really much of a concern here; it's statted out for BTRC's entry into the Univeral RPG System arena (EABA), but you can make use of whatever gear and creatures you already have in your system of choice and just add the elements you need.
Up Next: Key Elements of the Setting